Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → 3-(6-Cyclopentylpyridin-2-yl)-7-trifluoromethylimidazo[1,2-alpha]pyrimidine

Participants

Reaction Steps

2-Bromo-6-cyclopentylpyridine (479 mg, 2.1 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.4 mmol) by the method of Example 1 to give 3-(6-cyclopentylpyridin-2-yl)-7-trifluoromethylimidazo[1,2-α]pyrimidine (49 mg) as a white solid: δH (400 MHz, DMSO) 1.70-1.87 (6H, m), 2.10-2.16 (2H, m), 7.29 (1H, d, J 7.4), 7.80 (1H, d, J 7.0), 7.87 (1H, t, J 7.8), 7.95-7.97 (1H, m), 8.84 (1H, s), 10.50 (1H, d, J 6.7); m/z (ES+) 332 (M++H).

Provenance & Evidence