Thiophene, 2,4-dibromo- → HCID 69559414, compound

Participants

Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine (547 mg, 2.06 mmol) was reacted with 2,4-dibromothiophene over 1 h as described in Example 17. The resulting crude residue was purified by column chromatography on silica, using 40% EtOAc in isohexanes as the eluent, to yield 3-(4-bromothien-2-yl)-7-trifluoromethylimidazo[1,2-α]pyrimidine (104 mg, 15%) after recystallisation from dichloromethane/isohexanes: δH (400 MHz, d6-DMSO) 7.57 (1H, d, J 8.3), 7.72 (1H, d, J 1.6), 8.10 (1H, d, J 1.6), 8.34 (1H, s), 9.34 (1H, d, J 7.0); m/z (ES+) 347, 349 (1:1) (M+).

Provenance & Evidence