Lawesson's reagent → HCID 87889787, compound

Participants

Reaction Steps

Lawesson's reagent (281 mg, 0.7 mmol) was added to a stirred suspension of the foregoing amide (160 mg, 0.7 mmol) in toluene (16 ml). The resulting mixture was heated at reflux for 2.5 h and then concentrated under reduced pressure while dry loading onto silica. Subsequent purification by column chromatography on silica using firstly diethyl ether and then EtOAc/ether gave 7-trifluoromethylimidazo[1,2-α]pyrimidine-3-carbothioamide (160 mg, 93%): δH (360 MHz, d6-DMSO) δ 7.80 (1H, d, J 7.2), 8.70 (1H, s), 9.73 (1H, s), 9.82 (1H, s), 10.87 (1H, d, J 7.2).

Provenance & Evidence