2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → HCID 10269701, compound

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Reaction Steps

The product of Example 25 (0.34 g, 1.0 mmol) was coupled to 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile following the procedure in Example 2 to give 2-{6-[7-(1-fluoro-1-methyl-ethyl)imidazo[1,2-α]pyrimidin-3-yl]pyridin-2-yl}benzonitrile (0.133 g, 37%) as a white solid: δH (360 MHz, CDCl3) 1.80 (6H, d, J 22), 7.38 (1H, dd, J 7 and 2), 7.59 (1H, ddd, J 8, 7 and 1), 7.75 (1H, ddd, J 8, 7 and 1), 7.80-7.96 (5H, m), 8.38 (1H, s), 10.36 (1H, d, J 7); m/z (ES+) 358 (M++H).

Provenance & Evidence