7-Tert-butylimidazo[1,2-a]pyrimidine → 2-[6-(7-Tert-butylimidazo[1,2-alpha]pyrimidin-3-yl)pyridin-2-yl]-5-fluorobenzonitrile
Reaktionsgleichung
[C:1]([C:5]1[CH:10]=[CH:9][N:8]2[CH:11]=[CH:12][N:13]=[C:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:15]1[N:20]=[C:19]([C:21]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=2[C:23]#[N:24])[CH:18]=[CH:17][CH:16]=1>>[C:1]([C:5]1[CH:10]=[CH:9][N:8]2[C:11]([C:15]3[N:20]=[C:19]([C:21]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=4[C:23]#[N:24])[CH:18]=[CH:17][CH:16]=3)=[CH:12][N:13]=[C:7]2[N:6]=1)([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Versuchsvorschrift
7-tert-Butylimidazo[1,2-α]pyrimidine was coupled with 2-(6-bromopyridin-2-yl)-5-fluorobenzonitrile as described in Example 27 to give 2-[6-(7-tert-butylimidazo[1,2-α]pyrimidin-3-yl)pyridin-2-yl]-5-fluorobenzonitrile (0.235 g, 63%) as a white powder: δH (360 MHz, CDCl3) 1.43 (9H, s), 7.05 (1H, d, J 7), 7.37-7.73 (6H, m), 7.81 (1H, s), 7.85 (1H, dd, J 8 and 1), 8.75 (1H, d, J 7); m/z (ES+) 371 (M++H).
Quellen und Nachweise
- ORD-Eintrag
- ord-ad849815dc224b2db50f427714ff3cd0
- Quelldatensatz
- uspto-grants-2006_04
- Patentnummer
- US07030128B2
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