2,6-Dibromopyridine → 2-(6-Bromopyridin-2-yl)-4-fluorobenzonitrile

HRID 1796045노트

반응식

HRID 1796045 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](B2OC(C)(C)C(C)(C)O2)[CH:3]=1.[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22](Br)[N:21]=1>>[Br:19][C:20]1[N:21]=[C:22]([C:4]2[CH:3]=[C:2]([F:1])[CH:9]=[CH:8][C:5]=2[C:6]#[N:7])[CH:23]=[CH:24][CH:25]=1

참가 물질

3

반응물 2

HCID 122742,6-DibromopyridineHCID 221807884-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

생성물 1

HCID 221807782-(6-Bromopyridin-2-yl)-4-fluorobenzonitrile

실험 절차

4-Fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile (synthesised as in Example 24) was coupled with 2,6-dibromopyridine as described in Example 27 to give 2-(6-bromopyridin-2-yl)-4-fluorobenzonitrile as a white solid: δH (360 MHz, d6-DMSO) 7.55-7.60 (1H, m), 7.67-7.84 (2H, m), 7.89-8.02 (2H, m), 8.12 (1H, dd, J 9 and 6).

출처 및 근거

ORD 기록
ord-9501c0cb9ae6422d8c608f9bfb4f6d3e
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030128B2

반응 노트

불러오는 중…