HCID 2797792, compound → HCID 17978961, compound

HRID 1796051Notes

Reaction equation

HRID 1796051 reaction equation
C([Sn](CCCC)(CCCC)[C:6]1[N:10]2[CH:11]=[CH:12][C:13]([C:15]([F:18])([F:17])[F:16])=[N:14][C:9]2=[N:8][CH:7]=1)CCC.Br[C:28]1[CH:29]=[CH:30][C:31]([N:34]2[CH:38]=[CH:37][CH:36]=[CH:35]2)=[N:32][CH:33]=1>>[N:34]1([C:31]2[CH:30]=[CH:29][C:28]([C:6]3[N:10]4[CH:11]=[CH:12][C:13]([C:15]([F:16])([F:17])[F:18])=[N:14][C:9]4=[N:8][CH:7]=3)=[CH:33][N:32]=2)[CH:38]=[CH:37][CH:36]=[CH:35]1

Participants

3

Reactant 2

HCID 2797792HCID 2797792, compoundHCID 11294484Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)-

Product 1

HCID 17978961HCID 17978961, compound

Procedure

3-Tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine was reacted with 5-bromo-2-(pyrrol-1-yl)pyridine by the method of Example 1 to afford 3-[2-(1H-pyrrol-1-yl)pyridin-5-yl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as a yellow solid: δH (400 MHz, CDCl3) 6.42 (2H, m), 7.28 (1H, d, J 8), 7.52 (1H, dd, J 8 and 1), 7.58 (2H, m), 7.92 (1H, dd, J 8 and 2), 8.14 (1H, s), 8.64 (1H, dd, J 2 and 1), 8.74 (1H, d, J 8), m/z (ES+) 329, 330 (M++H).

Sources & evidence

ORD record
ord-126a1f0640404f2788d88f68a6837a27
Source dataset
uspto-grants-2006_04
Patent number
US07030128B2

Reaction notes

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