2,4-Dichloropyrimidine → 3-(2-Chloropyrimidin-4-yl)-7-(1-methyl-1-triethylsilanyloxyethyl)-imidazo[1,2-alpha]pyrimidine

Participants

Reaction Steps

7-(1-Methyl-1-triethylsilanyloxyethyl)-3-tributylstannyl-imidazo[1,2-α]pyrimidine was reacted with 2,4-dichloropyrimidine by the method of Example 5 to afford 3-(2-chloropyrimidin-4-yl)-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine as a white solid: δH (400 MHz, CDCl3) 0.70 (6H, q, J 8.0), 1.00 (9H, t, J 8.0), 1.69 (6H, s), 7.57 (1H, d, J 5.5), 7.67 (1H, d, J 7.0), 8.53 (2H, m), 10.07 (1H, d, J 7.0); m/z (ES+) 403 (M++H).

Provenance & Evidence