3-(Diethylboryl)pyridine → 7-(1-Methyl-1-triethylsilanyloxyethyl)-3-[2-(pyridin-3-yl)pyrimidin-4-yl]imidazo[1,2-alpha]pyrimidine

Participants

Reaction Steps

3-(2-Chloropyrimidin-4-yl)-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine was reacted with diethyl(3-pyridyl)borane by the method of Example 35 to afford 7-(1-methyl-1-triethylsilanyloxyethyl)-3-[2-(pyridin-3-yl)pyrimidin-4-yl]imidazo[1,2-α]pyrimidine as a white solid: δH (400 MHz, CDCl3) 0.73 (6H, q, J 8.1), 1.01 (9H, t, J 8.0), 1.72 (6H, s), 7.46-7.53 (2H, m), 7.61 (1H, d, J 5.5), 7.67 (1H, d, J 7.0), 8.52 (1H, s), 8.72-8.79 (2H, m), 9.71 (1H, m), 10.24 (1H, d, J 7.0); m/z (ES+) 447 (M++H).

Provenance & Evidence