2-Bromo-6-morpholinopyridine → HCID 10132526, compound

Participants

Reaction Steps

4-(6-Bromopyridin-2-yl)morpholine (0.46 g, 1.9 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.8 mmol) by the method of Example 1. Purification by chromatography on silica gel eluting with dichloromethane on a gradient of methanol (0-10%) and crystallisation from ethyl acetate-isohexane gave 3-[6-(morpholin-4-yl)pyridin-2-yl]-7-trifluoromethylimidazo[1,2-α]pyrimidine (220 mg) as a yellow solid: δH (400 MHz, CDCl3) 3.57 (4H, t, J 5), 3.90 (4H, t, J 5), 6.65 (1H, d, J 8), 7.20 (1H, d, J 8), 7.33 (1H, d, J 7), 7.65 (1H, dd, J 8 and 8), 8.42 (1H, s), 10.19 (1H, d, J 7); m/z (ES+) 350 (M++H).

Provenance & Evidence