2-Bromo-6-phenylpyridine → HCID 10268818, compound

Participants

Reaction Steps

2-Bromo-6-phenylpyridine (0.17 g, 0.7 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (0.9 mmol) by the method of Example 1. Purification by chromatography on silica gel eluting with dichloromethane on a gradient of methanol (0-10%) and trituration with ethyl acetate gave 3-(6-phenylpyridin-2-yl)-7-trifluoromethylimidazo[1,2-α]pyrimidine (82 mg) as a pale yellow solid: δH (400 MHz, CDCl3) 7.39 (1H, d, J 7), 7.53 (3H, m), 7.70 (1H, d, J 8), 7.78 (1H, d, J 8), 7.91 (1H, dd, J 8 and 8), 8.01 (2H, d, J 8), 8.53 (1H, s), 10.62 (1H, d, J 7); m/z (ES+) 341 (M++H).

Provenance & Evidence