Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 10132405, compound

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Reaction Steps

2-Bromo-6-(isothiazol-4-yl)pyridine (0.27 g, 1.13 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (1.13 mmol) by the method of Example 1. Purification by chromatography on silica gel eluting with isohexane on a gradient of ethyl acetate (20-80%) and trituration with isohexane gave 3-[6-(isothiazol-4-yl)pyridin-2-yl]-7-trifluoromethylimidazo[1,2-α]pyrimidine (130 mg) as a pale yellow solid: δH (400 MHz, CDCl3) 7.41 (1H, d, J 7), 7.62 (1H, d, J 8), 7.78 (1H, d, J 8), 7.92 (1H, dd, J 8 and 8), 8.56 (1H, s), 9.12 (1H, s), 9.13 (1H, s), 10.45 (1H, d, J 7); m/z (ES+) 347 (M++H).

Provenance & Evidence