HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorobenzeneboronic acid → HCID 69559439, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorobenzeneboronic acid | HCID 2734337 | — |
| Reactant | 3-(2-Chloropyrimidin-4-yl)-7-(1-methyl-1-triethylsilanyloxyethyl)-imidazo[1,2-alpha]pyrimidine | HCID 87889549 | — |
| Product | HCID 69559439 | HCID 69559439 | — |
Reaction Steps
3-(2-Chloropyrimidin-4-yl)-7-(1-methyl-1-triethylsilanyloxyethyl)-imidazo-[1,2-α]pyrimidine (250 mg, 0.62 mmol) and 3,4-difluorobenzeneboronic acid (196 mg, 1.24 mmol) were reacted together as described in Example 61. Purification by column chromatography on silica using 2.5% MeOH/CH2Cl2 gave 3-[2-(3,4-difluorophenyl)pyrimidin-4-yl]-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine: m/z (ES+) 482 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030128B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-97d56c4a43c64ba4a4b60f78cb9405d6 |
| Source note | uspto-grants-2006_04 |