Morpholine → 2-Methylene4-morpholin-4-yl-4-oxo-butyric acid

Participants

Reaction Steps

Morpholine (23.6 g, 271 mmol) was slowly added to a stirred solution of itaconic anhydride (30.36 g, 271 mmol) suspended in dichloromethane (200 mL) below −5° C. and stirred at that temperature for 1 hr. The reaction mixture was allowed to slowly warm up to room temperature and evaporated under reduced pressure below 30° C. to give a viscous oil. This was triturated with ethyl acetate to give 2-Methylene-4-morpholin-4-yl-4-oxo-butyric acid as white solid (36.8 g, 68%). The product was used without further purification in the next step.

Provenance & Evidence