Water → 3-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid

HRID 1796141Notes

Reaction equation

HRID 1796141 reaction equation
C([O:3][C:4](=[O:23])[CH:5]([CH2:15][O:16][CH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)[CH2:6][S:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)C.[OH-].[Na+].O>C(O)C>[CH2:8]([S:7][CH2:6][CH:5]([CH2:15][O:16][CH:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1)[C:4]([OH:23])=[O:3])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 694384543-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid ethyl ester

Product 1

HCID 220539503-Benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-benzylsulfanyl-2-(tetrahydro-pyran-4-yloxymethyl)-propionic acid ethyl ester (1.27 g) in ethanol (30 ml) was treated with 2N NaOH (9.4 ml) overnight. Usual water work up gave the title compound as white solid; MS: 333 (M+Na), 311 (M+1); LCMS retention time 3.7 minutes.

Sources & evidence

ORD record
ord-9bf9cd39efec4a2da93430516d5078e0
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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