(R)-2-((S)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid → (R)-2-(1-Methoxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid

HRID 1796157Notes

Reaction equation

HRID 1796157 reaction equation
O[C@@H]([C@@H](CCCC1C=CC=CC=1)C(O)=O)C(N1CCOCC1)=O.C[O:25][C:26](=[O:48])[C@@H:27]([CH:37]([O:46][CH3:47])[C:38]([N:40]1[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1)=[O:39])[CH2:28][CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH3:47][O:46][CH:37]([C@@H:27]([CH2:28][CH2:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:26]([OH:48])=[O:25])[C:38]([N:40]1[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1)=[O:39]

Participants

3

Reactant 2

HCID 58619483(R)-2-((S)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acidHCID 69619099(R)-2-(1-Methoxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid methyl ester

Product 1

HCID 58619482(R)-2-(1-Methoxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid

Procedure

It is similarly prepared according to the procedure of (22), but using (R)-2-(1-Methoxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid methyl ester (6b).

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-63586ba683f444b58caf4bdcf24536a1
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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