4-Morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyric acid → N-[(S)-1-(5-Ethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-4-morpholin-4-yl-4-oxo-2-phenylmethanesulfonylmethyl-butyramide

HRID 1796165Notes

Reaction equation

HRID 1796165 reaction equation
[N:1]1([C:7](=[O:24])[CH2:8][CH:9]([CH2:13][S:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:16])=[O:15])[C:10]([OH:12])=O)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:25][CH:26]([CH2:36][CH3:37])[C@@H:27]([C:29]1[N:33]=[C:32]([CH2:34][CH3:35])[O:31][N:30]=1)[OH:28]>>[CH2:34]([C:32]1[O:31][N:30]=[C:29]([C:27]([C@@H:26]([NH:25][C:10](=[O:12])[CH:9]([CH2:13][S:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:16])=[O:15])[CH2:8][C:7]([N:1]2[CH2:2][CH2:3][O:4][CH2:5][CH2:6]2)=[O:24])[CH2:36][CH3:37])=[O:28])[N:33]=1)[CH3:35]

Participants

3

Reactant 2

HCID 220539874-Morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyric acidHCID 67301133(S)-2-Amino-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol

Product 1

HCID 58619526N-[(S)-1-(5-Ethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-4-morpholin-4-yl-4-oxo-2-phenylmethanesulfonylmethyl-butyramide

Procedure

It is similarly prepared according to general procedure given for Example 2 above but using 4-Morpholin-4-yl-4-oxo-2-phenylmethanesulfonylmethyl-butyric acid and (S)-2-Amino-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-3a97f9b967de4a2d9add23115510f4f9
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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