(R)-2-Cyclohexylmethyl-4-morpholin-4-yl-4-oxo-butyric acid → (R)-2-Cyclohexylmethyl-N-[(S)-1-(5-ethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-4-morpholin-4-yl-4-oxo-butyramide

HRID 1796168Notes

Reaction equation

HRID 1796168 reaction equation
[CH:1]1([CH2:7][C@H:8]([CH2:12][C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])[C:9]([OH:11])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O.[NH2:28][CH:29]([CH2:39][CH3:40])[C@@H:30]([C:32]1[N:36]=[C:35]([CH2:37][CH3:38])[O:34][N:33]=1)[OH:31]>>[CH:1]1([CH2:7][C@H:8]([CH2:12][C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])[C:9]([NH:28][C@H:29]([C:30]([C:32]2[N:36]=[C:35]([CH2:37][CH3:38])[O:34][N:33]=2)=[O:31])[CH2:39][CH3:40])=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 59972959(R)-2-Cyclohexylmethyl-4-morpholin-4-yl-4-oxo-butyric acidHCID 69427127(S)-2-amino-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol trifluoroacetate

Product 1

HCID 58619520(R)-2-Cyclohexylmethyl-N-[(S)-1-(5-ethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-4-morpholin-4-yl-4-oxo-butyramide

Procedure

It is similarly prepared according to general procedure given for example 8 above but using (R)-2-Cyclohexylmethyl-4-morpholin-4-yl-4-oxo-butyric acid and (S)-2-Amino-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol; compound with trifluoro-acetic acid.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-8e1a00dbcab743749cf9f682081d4139
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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