4-Morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyric acid → N-[(S)-1-(Benzoxazole-2-carbonyl)-butyl]-4-morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyramide

HRID 1796170Notes

Reaction equation

HRID 1796170 reaction equation
[N:1]1([C:7](=[O:23])[CH2:8][CH:9]([CH2:13][CH:14]2[CH2:16][CH:15]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]([OH:12])=O)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:24][CH:25]([CH2:37][CH2:38][CH3:39])[C@@H:26]([C:28]1[O:29][C:30]2[CH:36]=[CH:35][CH:34]=[CH:33][C:31]=2[N:32]=1)[OH:27]>>[O:29]1[C:30]2[CH:36]=[CH:35][CH:34]=[CH:33][C:31]=2[N:32]=[C:28]1[C:26]([C@@H:25]([NH:24][C:10](=[O:12])[CH:9]([CH2:13][CH:14]1[CH2:16][CH:15]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:8][C:7]([N:1]1[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1)=[O:23])[CH2:37][CH2:38][CH3:39])=[O:27]

Participants

3

Reactant 2

HCID 221799094-Morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyric acidHCID 53785501(S)-2-Amino-1-benzoxazol-2-yl-pentan-1-ol

Product 1

HCID 10414238N-[(S)-1-(Benzoxazole-2-carbonyl)-butyl]-4-morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyramide

Procedure

It is similarly prepared according to general procedure given for example 10 above but using 4-Morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyric acid and (S)-2-Amino-1-benzoxazol-2-yl-pentan-1-ol.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-f6ebd8c4faeb437c8921dbfbc333d38f
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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