(R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid → (R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid [(S)-1-(benzoxazole-2-carbonyl)-butyl]-amide

HRID 1796171Notes

Reaction equation

HRID 1796171 reaction equation
[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][C@H:4]([CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])[C:5]([OH:7])=O.[NH2:19][CH:20]([CH2:32][CH2:33][CH3:34])[C@@H:21]([C:23]1[O:24][C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=1)[OH:22]>>[O:24]1[C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=[C:23]1[C:21]([C@@H:20]([NH:19][C:5](=[O:7])[C@@H:4]([CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])[CH2:3][C:2]([CH3:1])([CH3:18])[CH3:17])[CH2:32][CH2:33][CH3:34])=[O:22]

Participants

3

Reactant 2

HCID 15975488(R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acidHCID 53785501(S)-2-Amino-1-benzoxazol-2-yl-pentan-1-ol

Product 1

HCID 44452769(R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid [(S)-1-(benzoxazole-2-carbonyl)-butyl]-amide

Procedure

It is similarly prepared according to general procedure given for example 10 above but using (R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid and (S)-2-Amino-1-benzoxazol-2-yl-pentan-1-ol.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-4f16ffee6f12451791bc08aaa961fcc9
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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