4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid → (r)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid[1-(3-phenyl-1,2,4-oxadiazole-5-carbonyl)-propyl]-amide

HRID 1796172Notes

Reaction equation

HRID 1796172 reaction equation
[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][CH:4]([CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])[C:5]([OH:7])=O.[NH2:19][CH:20]([CH2:34][CH3:35])[C@@H:21]([C:23]1[O:27][N:26]=[C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:24]=1)[OH:22]>>[C:28]1([C:25]2[N:24]=[C:23]([C:21]([CH:20]([NH:19][C:5](=[O:7])[C@@H:4]([CH2:8][C:9]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)=[O:10])[CH2:3][C:2]([CH3:1])([CH3:18])[CH3:17])[CH2:34][CH3:35])=[O:22])[O:27][N:26]=2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 221798834,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acidHCID 68824651(S)-2-Amino-1-(3-phenyl-1,2,4-oxadiazol-5-yl)-butan-1-ol

Product 1

HCID 58619521(r)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid[1-(3-phenyl-1,2,4-oxadiazole-5-carbonyl)-propyl]-amide

Procedure

It is similarly prepared according to general procedure given for example 10 above but using 4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid and (S)-2-Amino-1-(3-phenyl-1,2,4-oxadiazol-5-yl)-butan-1-ol.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-24891bdfa6f5476391c4e663d4971e76
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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