(S)-2-Amino-1-benzoxazol-2-yl-pentan-1-ol → 4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid [(S)-1-(benzoxazole-2-carbonyl)-butyl]-amide

HRID 1796174Notes

Reaction equation

HRID 1796174 reaction equation
[CH3:1][C:2]([CH3:24])([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:3][C@H:4]([CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])[C:5]([OH:7])=O.[NH2:25][CH:26]([CH2:38][CH2:39][CH3:40])[C@@H:27]([C:29]1[O:30][C:31]2[CH:37]=[CH:36][CH:35]=[CH:34][C:32]=2[N:33]=1)[OH:28]>>[O:30]1[C:31]2[CH:37]=[CH:36][CH:35]=[CH:34][C:32]=2[N:33]=[C:29]1[C:27]([C@@H:26]([NH:25][C:5](=[O:7])[CH:4]([CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])[CH2:3][C:2]([CH3:1])([CH3:24])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:38][CH2:39][CH3:40])=[O:28]

Participants

3

Reactant 2

HCID 53785501(S)-2-Amino-1-benzoxazol-2-yl-pentan-1-olHCID 58619484(R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid

Product 1

HCID 103923254,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid [(S)-1-(benzoxazole-2-carbonyl)-butyl]-amide

Procedure

It is similarly prepared according to general procedure given for example 10 above but using (R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid and (S)-2-Amino-1-benzoxazol-2-yl-pentan-1-ol.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-b7d17ff954c04a709984ad9dbaf407f4
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

Loading…