4-Morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyric acid → 4-Morpholin-4-yl-N-[1-(oxazole-2-carbonyl)-3-phenyl-propyl]-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyramide

HRID 1796177Notes

Reaction equation

HRID 1796177 reaction equation
[N:1]1([C:7](=[O:23])[CH2:8][CH:9]([CH2:13][CH:14]2[CH2:16][CH:15]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10](O)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:24][CH:25]([CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C@@H:26]([C:28]1[O:29][CH:30]=[CH:31][N:32]=1)[OH:27]>>[N:1]1([C:7](=[O:23])[CH2:8][CH:9]([CH2:13][CH:14]2[CH2:16][CH:15]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]([NH:24][CH:25]([C:26]([C:28]2[O:29][CH:30]=[CH:31][N:32]=2)=[O:27])[CH2:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 221799094-Morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyric acidHCID 69619089(S)-2-Amino-1-oxazol-2-yl-4-phenyl-butan-1-ol

Product 1

HCID 100299254-Morpholin-4-yl-N-[1-(oxazole-2-carbonyl)-3-phenyl-propyl]-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyramide

Procedure

It is similarly prepared according to general procedure given for example X above but using 4-Morpholin-4-yl-4-oxo-2-(2-phenyl-cyclopropylmethyl)-butyric acid and (S)-2-Amino-1-oxazol-2-yl-4-phenyl-butan-1-ol.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-796a2ce615e9409c97d9228cbb9dff4e
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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