HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (r)-5-(2-Difluoromethoxy-phenyl)-2-((s)-1-hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid[(s)-1-(oxazole-2-carbonyl)-propyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-5-(2-Difluoromethoxy-phenyl)-2-((S)-1-hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid | HCID 58619505 | — |
| Reactant | (S)-2-Amino-1-oxazol-2-yl-butan-1-one | HCID 58619524 | — |
| Product | (r)-5-(2-Difluoromethoxy-phenyl)-2-((s)-1-hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid[(s)-1-(oxazole-2-carbonyl)-propyl]-amide | HCID 58619508 | — |
Reaction Steps
It is similarly prepared according to the general procedure for Example 10 using (S)-2-Amino-1-oxazol-2-yl-butan-1-one; hydrochloride as the amino component and (R)-5-(2-Difluoromethoxy-phenyl)-2-((S)-1-hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-pentanoic acid as the acidic component but without further oxidation step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030116B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-65e6e246e67d4c35969e4e448fbcb326 |
| Source note | uspto-grants-2006_04 |