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Trityl chloride → (2R,4R)-4-Hydroxy-1-trityl-pyrrolidine-2-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trityl chloride | HCID 6456 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | (2R,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate | HCID 7020012 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | (2R,4R)-4-Hydroxy-1-trityl-pyrrolidine-2-carboxylic acid methyl ester | HCID 68685802 | 100% |
反応手順
Into a solution of 1 (10 g, 55 mmol) in anhydrous CHCl3 (100 mL) was added triethylamine (19 mL, 138 mmol) and triphenylmethyl chloride (14.5 g, 52 mmol). The mixture was stirred at RT for 3 d before concentrating and redissolving in EtOAc. The solution was washed sequentially with 10% aq. citric acid, water, and brine before drying over MgSO4 and concentrating under reduced pressure to give 2 (20 g, 100%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07030141B2 |
| 出典データセット | uspto-grants-2006_04 |
| ORD ID | ord-03d797ef84384cc3a42572b877c4cb58 |
| 出典メモ | uspto-grants-2006_04 |