Sodium borohydride → HCID 22181665, compound

Participants

Reaction Steps

To a stirred solution of 87 mg (0.4 mmol) 5-bromo-1-ethyl-4-methyl-1H-imidazole-2-carbaldehyde in 5 ml of MeOH is added 46 mg (1.2 mmol) of NaBH4. The mixture is stirred at room temperature for 3 hours and the solvent is removed in vacuo. The residue is dissolved in 15 ml of EtOAc and washed with 10 ml of water and 10 ml of brine. The organic phase is dried (Na2SO4), filtered and evaporated. This clear oil is used in next step without further purification. MS m/z (M+1)+ 219.

Provenance & Evidence