Trimethylsilylacetylene → HCID 22181689, compound

Participants

Reaction Steps

[3-(4-Bromobenzenesulfonyl)-6-methylpyridin-2-yl]-(2,4,6-trimethylphenyl)-amine, prepared as described in Example 46, (100 mg, 0.225 mmol), Pd(PPh3)2Cl2 (7.9 mg, 0.011 mmol), CuI (2.1 mg, 0.011 mmol) and trimethylsilylacetylene (0.038 mL, 0.270 mmol) were heated at 50° C. in Et3N (0.5 mL) for 16 h. The reaction mixture was stripped in vacuo and the residue was chromatographed on silica gel using 10% EtOAc/hexanes as eluent to give 53 mg [6-methyl-3-(4-trimethylsilanylethynyl-benzenesulfonyl)-pyridin-2-yl]-(2,4,6-trimethylphenyl)-amine.

Provenance & Evidence