HCID 86588556, compound → HCID 86588557, compound

Participants

Reaction Steps

To a parr shaker under nitrogen atmosphere was charged 3-aminomethylbenzimidazole-4 nitro benzoic acid methylester (10 g, 0.037 mol, 1.0 eq) and 180 ml of methanol. To the slurry was charged 1 g of 10% Palladium on carbon This was placed under 55 psi hydrogen atmosphere and shaken for 16 hours. The reaction was removed under nitrogen atmosphere and filtered over a bed of celite under an atmosphere of nitrogen and the celite/Pd/c washed with 500 ml of methanol (degassed with nitrogen) and the combined organics concentrated to an off white solid. Yield 96%.

Provenance & Evidence