Piperidine → HCID 69529238, compound

Participants

Reaction Steps

8.1 g (0.025 mole) of (2S)-2-tert-butoxycarbonylamino-7-hydroxycarbonylmethoxy-tetralin, 2.5 ml (0.025 mole) of piperidine, 11 g (0.025 mole) of benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and 5.3 ml of triethylamine in 250 ml of dimethylformamide were mixed at ambient temperature for 6 hours. The solvent was evaporated off, the residue was taken up in water, it was extracted with ethyl acetate, the organic phase was washed with a saturated NaHCO3 solution, filtered over celite and washed with a dilute solution of acetic acid and with water. It was dried and the solvent was evaporated off under reduced pressure. The product was purified by crystallization from a 1:1 ethyl/hexane mixture. The product of the heading was obtained.

Provenance & Evidence