反应详情

温度

90 °C

Following general procedure 2B: A mixture of N,N-diethyl-4-fluoro-3-nitrobenzamide (0.200 g, 0.833 mmol), N-(2-aminoethyl)acetamide (0.077 g, 0.757 mmol) in 80% aq. EtOH (5 mL) was heated at 90° C. overnight. After work-up, the crude product was purified by silica gel column chromatography (100% EtOAc to 5% MeOH/EtOAc) to provide the title compound (0.152 g, 63%) as a bright yellow solid. 1H-NMR (CDCl3): δ 8.27 (d overlapping with br s, J=2.0 Hz, 2H), 7.55 (dd, J=8.4 Hz, J=2.0 Hz, 1H), 6.99 (d, J=9.2 Hz, 1H), 6.06 (br s, 1H), 3.58–3.50 (m, 4H), 3.44 (br s, 4H), 2.02 (s, 3H), 1.22 (t, J=7.2 Hz, 6H). MS (ESI) (M+H)+=323.

1. customAfter work-up, the crude product was purified by silica gel column chromatography (100% EtOAc to 5% MeOH/EtOAc)