Ethyl 3-{4-[(diethylamino)carbonyl]-2-nitroanilino}propanoate → Ethyl 3-{2-amino-4-[(diethylamino)carbonyl]anilino}propanoate

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Reaction Steps

Following general procedure 2C: A mixture of ethyl 3-{4-[(diethylamino)carbonyl]-2-nitroanilino}propanoate (0.150 g, 0.445 mmol) and 10% Pd/C in EtOAc (15 mL) was hydrogenated overnight at 40 psi. Usual work-up provided the title compound (0.158 g) which was used without further purification. 1H-NMR (CDCl3): δ 6.86 (dd, J=8.4 Hz, J=2.0 Hz, 1H), 6.80 (d, J=2.0 Hz, 1H), 6.62 (d, J=8.4 Hz, 1H), 4.18 (q, J=7.2 Hz, 2H), 3.46 (t and overlapping br s, J=5.6 Hz, 6H), 2.66 (t, J=6.8 Hz, 2H), 1.28 (t, J=7.2 Hz, 3H), 1.18 (t, J=6.8 Hz, 6H). MS (ESI) (M+H)+=308.

Provenance & Evidence