Hydrochloric Acid → 1-(cyclopropylmethyl)-2-[(5-ethoxy-2-pyridinyl)methyl]-1H-benzimidazole-5-carboxylic acid

Participants

Reaction Steps

To a solution 1-(cyclopropylmethyl)-2-[(5-ethoxy-2-pyridinyl)methyl]-1H-benzimidazole-5-carbonitrile (400 mg, 1.203 mmol) in 1:1 EtOH:H2O (12 mL) was added KOH (269 mg, 4.81 mmol). The resulting mixture was refluxed for 36 h. The mixture was acidified with 1 N HCl to pH˜6.0. The precipitate (397 mg, 94%) was used in the subsequent step without further purification. MS (ESI) (M+H)+=352.

Provenance & Evidence