Cyclopropanemethanamine → Methyl 4-[(cyclopropylmethyl)amino]-3-nitrophenylcarbamate

Participants

Reaction Conditions

Reaction Steps

Following general procedure 2B: To methyl 4-fluoro-3-nitrophenylcarbamate (6.50 g, 30.35 mmol, from previous step) in 80% aqueous ethanol (100 mL) was added cyclopropanemethylamine (5.00 mL, 57,65 mmol) at room temperature. The reaction mixture was heated at 60° C. overnight. After the usual work up, the crude product, which precipitated out, was collected (8.21 g). MS (ESI) (M+H)+=266.

Provenance & Evidence