HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzeneacetic acid, 4-ethoxy- → HCID 22181316, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzeneacetic acid, 4-ethoxy- | HCID 78631 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 22181329 | HCID 22181329 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22181316 | HCID 22181316 | 86% |
Reaction Steps
Following procedure 13B, N-{3-amino-4-[(cyclopropylmethyl)amino]phenyl}acetamide (5.50 g, 25.11 mmol), DIPEA (6.50 ml, 37.5 mmol), 4-ethoxyphenylacetic acid (5.40 g, 30.0 mmol) and HATU (11.40 g, 30.0 mmol) in DMF (100 ml) were stirred at room temperature overnight. Isolated the desired product (4.5 g, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030139B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-0fb23f5cadd84f4393042389f1bd8809 |
| Source note | uspto-grants-2006_04 |