Potassium Hydroxide → HCID 22181285, compound

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Reaction Steps

A mixture of N-[1-(cyclopropylmethyl)-2-[1-(4-ethoxyphenyl)ethyl]-1H-benzimidazol-5-yl]-N-methyl acetamide (2.43 g, 5.64 mmol) and 40% KOH (50 ml) in EtOH was heated for 20 h at reflux. After being cooled down, the mixture was concentrated to a small volume (50 mL) and diluted with H2O (50 mL) which was extracted with dichloromethane (4×50 mL). The combined organic phases were dried with Na2SO4. After filtration and evaporation of the solvent, the residue was purified by MPLC using EtOAc on silica gel to give 1.93 g (99%) of the title compound as an off-white solid. MS (ESI) (M+H)+=350.37.

Provenance & Evidence