Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- → HCID 22179680, compound

Participants

Reaction Steps

3-Cyano-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-6-carboxylic acid (2-amino-phenyl)-amide 371 (4 mg, 0.008 mmol) and a small pinch of 10-camphorsulfonic acid was heated in toluene (1.0 ml) at 110° C. for 5 hrs. The reaction mixture was purified by silica gel flash chromatography to isolate 373 as yellow film (1.9 mg, 33%). [M+H]+=436.1.

Provenance & Evidence