反应详情

6-Amino-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile hydrochloride (10 mg, 0.026 mmol), benzaldehyde (2.8 mg, 0.026 mmol) and acetic acid (0.5 ml) in 1,2-dichloroethane (1.0 ml) were stirred at RT. After 20 minutes, NaBH(OAc)3 was added and the reaction mixture was stirred for additional 15 minutes, quenched with saturated NH4OH (4.0 ml), extracted with dichloromethane (3×3 ml), dried over Na2SO4, concentrated and purified by silica gel flash chromatography to isolate 376 as a yellow film (1.3 mg, 11%). [M+H]+=446.2.

1. customquenched with saturated NH4OH (4.0 ml)
2. extractionextracted with dichloromethane (3×3 ml)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. custompurified by silica gel flash chromatography