1-Benzyl-4-piperidylamine → HCID 21025151, compound

HRID 1796620Notes

Reaction equation

HRID 1796620 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6]([CH3:17])=[C:7]2[C:12](Cl)=[C:11]([C:14]#[N:15])[CH:10]=[N:9][N:8]2[CH:16]=1)=[O:4].[NH2:18][CH:19]1[CH2:24][CH2:23][N:22]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:21][CH2:20]1.COC(C1C(C)=C2C(NC3C=CC(OC4C=CC=CC=4OC(C(OC(C)(C)C)=O)(C)C)=CC=3)=C(C#N)C=NN2C=1)=O>>[CH3:1][O:2][C:3]([C:5]1[C:6]([CH3:17])=[C:7]2[C:12]([NH:18][CH:19]3[CH2:24][CH2:23][N:22]([CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:21][CH2:20]3)=[C:11]([C:14]#[N:15])[CH:10]=[N:9][N:8]2[CH:16]=1)=[O:4]

Participants

4

Reactant 3

HCID 4158521-Benzyl-4-piperidylamineHCID 22179696HCID 22179696, compoundHCID 69327667HCID 69327667, compound

Product 1

HCID 21025151HCID 21025151, compound

Procedure

The title compound was prepared from 4-chloro-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid methyl ester (prepared using the procedure of Example 1D) (65.0 mg, 0.246 mmol) and 4-amino-1-benzylpiperidine (52.6 μl, 0.258 mmol) by a route analogous to that used for the preparation of compound 388D. It (100 mg, 97%) was a white crystalline solid. LCMS Found: (M+H)+=418.2

Workup

  1. customprepared

Sources & evidence

ORD record
ord-01ddb19d15bb4fb7bd49b018a6c2bf5f
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

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