反应详情

温度

80 °C

A mixture of 2-amino-isoindole-1,3-dione (5.0 g, 30.9 mmol), ethyl bromoacetate (10.32 g, 61.8 mmol), K2CO3 (8.5 g, 61.8 mmol) in DMA (38 ml) was heated at 80° C. for 7 h. After cooling to rt, the mixture was filtered, and the filtrate was diluted with EtOAc, washed with water and brine, dried and concentrated. The residue was treated with EtOAc and hexanes to give 393A (4.4 g, 57%) as yellow crystals.

1. temperatureAfter cooling to rt
2. filtrationthe mixture was filtered
3. additionthe filtrate was diluted with EtOAc
4. washwashed with water and brine
5. customdried
6. concentrationconcentrated
7. additionThe residue was treated with EtOAc and hexanes