反应详情

A mixture of 393D (0.58 g, 1.58 mmol) and NH2NH2 (60 μl, 2.21 mmol) in EtOH (5 ml) was stirred at rt overnight, filtered through Celite, the filtrate was concentrated and the residue was purified by silica gel flash column chromatography to give 393E (0.30 g, 75%) (0%-5% EtOAc—CH2Cl2).

1. filtrationfiltered through Celite
2. concentrationthe filtrate was concentrated
3. customthe residue was purified by silica gel flash column chromatography