HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1796629Generated: November 2, 2026
Phenol → 2-(5-Nitro-2-phenoxy-benzyloxy)-tetrahydro-pyran
https://huagongshe.com/reaction/1796629
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 2-(2-Fluoro-5-nitro-benzyloxy)-tetrahydro-pyran | HCID 22179631 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(5-Nitro-2-phenoxy-benzyloxy)-tetrahydro-pyran | HCID 22179476 | 90% |
Reaction Steps
A mixture of 394B (125 mg, 0.49 mmol), phenol (55 mg, 0.59 mmol) and t-BuOK (65 mg, 0.58 mmol) in toluene (1 ml) was heated at 120° C. for 2 h. and then diluted with water, extracted with EtOAc, dried and concentrated to give 394C (145 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07030112B2 |
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| Source dataset | uspto-grants-2006_04 |
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| ORD ID | ord-75d934913ebe4b29a775d5371b5102d4 |
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| Source note | uspto-grants-2006_04 |
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