(4-Aminophenoxy)benzene → HCID 21025113, compound

HRID 1796633Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13](Cl)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2].[O:19]([C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.COC(C1C(C)=C2C(NC3C=CC(OC4C=CC=CC=4OC(C(OC(C)(C)C)=O)(C)C)=CC=3)=C(C#N)C=NN2C=1)=O>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13]([NH:32][C:29]3[CH:28]=[CH:27][C:26]([O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:31][CH:30]=3)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2]

Participants

Reactant 3

HCID 8764(4-Aminophenoxy)benzene

HCID 21025099HCID 21025099, compound

HCID 22179696HCID 22179696, compound

Product 1

HCID 21025113HCID 21025113, compoundYield 85%

Procedure

Compound 396A (1.85 g, 85%) was prepared from 4-chloro-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester (Example 1D) (1.4 g, 5.32 mmol) and 4-phenoxy-phenylamine (1.1 g, 5.94 mmol) by a route analogous to that used for the preparation of compound 388D.

Sources & evidence

ORD record: ord-b3d02c5cf9324318815f4b3a4ae2ecfb
Source dataset: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07030112B2

Reaction notes

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