Hydrochloric Acid → 3-Cyano-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-7-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 406 (15.6 mg, 0.039 mmol) and 1N NaOH (150 μl, 0.15 mmol) in EtOH (5 ml) was stirred at 50-70° C. for 15 h. 1N HCl (150 μl, 0.15 mmol) was added, solvent was removed, and the residue was purified by preparative TLC to give the title compound (14.1 mg, 98%) as a tan solid. LCMS Found: (M+H)+=371.1

Provenance & Evidence