Thiourea → HCID 22179682, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 425A (20 mg, 0.04 mmol) and thiourea (5.4 mg, 0.068 mmol) in acetone (2 ml) was heated at 70° C. for 2.5 h, then stirred at rt overnight. Filtered, the solid was washed with cold acetone and hexanes, dried to give the hydrobromide salt of 425 (14 mg, 63%) as a white solid. It has a retention time of 5.47 min (standard LC1 method, 8 min run). MS Found: (M+H)+=472.0

Provenance & Evidence