3-Fluoro-4-nitrophenol → 4-Amino-3-fluorophenol

HRID 1796667Notes

Reaction equation

HRID 1796667 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O.ClC1C=C(N)C=CC=1SC1N(C)C=CN=1>>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([OH:11])=[CH:3][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 5209483-Fluoro-4-nitrophenolHCID 114590883-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)phenylamine

Product 1

HCID 27359194-Amino-3-fluorophenolYield 92.3%

Procedure

Compound 427A (1.49 g, 92%) was prepared from 3-fluoro-4-nitro-phenol (2.0 g, 12.7 mmol) by a route analogous to that used for the preparation of compound 426B. It is a yellow solid and has a retention time of 4.79 min (standard LC1 method, 8 min run). MS Found: (M+H)+=128.1

Workup

  1. customa retention time of 4.79 min (standard LC1 method, 8 min run)

Sources & evidence

ORD record
ord-a7bc0e7fb0e04895b1d3ef4216293369
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

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