反应详情

Compound 427 (361 mg, 83%) was prepared from 4-chloro-3-cyano-5-methyl-pyrrolo]1,2-b]pyridazine-6-carboxylic acid ethyl ester (Example 1D) (264 mg, 1.0 mmol) and 427B (210 mg, 1.0 mmol) by a route analogous to that used for the preparation of compound 426. It is a dim yellow solid and has a retention time of 6.76 min (standard LC1 method, 8 min run). MS Found: (M+H)+=438.1

1. customa retention time of 6.76 min (standard LC1 method, 8 min run)