反应详情

To a solution of 433A (5.05 g, 15.2 mmol) in a mixed solvent of THF/MeOH (45 ml, 2/1) was added 2N NaOH (15.2 ml, 30.4 mmol). The mixture was stirred at rt for 2.5 h, concentrated. The residue was purified by flash chromatography on silica gel (2%-5% MeOH—CH2Cl2) gave 433B (4.38 g, 91%) as a light yellow solid.

1. concentrationconcentrated
2. customThe residue was purified by flash chromatography on silica gel (2%-5% MeOH—CH2Cl2)