HRID1796684

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21025099

未命名化合物

结构：COC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4OC(C)(C)C(=O)OC(C)(C)C)cc3)c2c1C

HCID22179696

未命名化合物

结构：CC(C)(Oc1ccccc1Oc1ccc(N)cc1)C(=O)NCCO

HCID22179742

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cn2ncc(C#N)c(Nc3ccc(Oc4ccccc4OC(C)(C)C(=O)NCCO)cc3)c2c1C

HCID21025115

未命名化合物

收率 83%

PROCEDURE

实验过程

Compound 433E (146 mg, 83%) was prepared from 4-chloro-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester (Example 1D) (126 mg, 0.476 mmol) and 433D (165 mg, 0.500 mmol) by a route analogous to that used for the preparation of compound 388D. It is a cream-colored crystalline solid. LCMS Found: (M+H)+=558.1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3d553aced7d4c5b9a929f70991adeef
来源数据集: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07030112B2
来源说明: uspto-grants-2006_04

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13](Cl)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2].[NH2:19][C:20]1[CH:42]=[CH:41][C:23]([O:24][C:25]2[CH:40]=[CH:39][CH:38]=[CH:37][C:26]=2[O:27][C:28]([CH3:36])([CH3:35])[C:29]([NH:31][CH2:32][CH2:33][OH:34])=[O:30])=[CH:22][CH:21]=1.COC(C1C(C)=C2C(NC3C=CC(OC4C=CC=CC=4OC(C(OC(C)(C)C)=O)(C)C)=CC=3)=C(C#N)C=NN2C=1)=O>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13]([NH:19][C:20]3[CH:42]=[CH:41][C:23]([O:24][C:25]4[CH:40]=[CH:39][CH:38]=[CH:37][C:26]=4[O:27][C:28]([C:29](=[O:30])[NH:31][CH2:32][CH2:33][OH:34])([CH3:35])[CH3:36])=[CH:22][CH:21]=3)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2]