HCID 21025099, compound → HCID 21025115, compound

HRID 1796684Notes

Reaction equation

HRID 1796684 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13](Cl)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2].[NH2:19][C:20]1[CH:42]=[CH:41][C:23]([O:24][C:25]2[CH:40]=[CH:39][CH:38]=[CH:37][C:26]=2[O:27][C:28]([CH3:36])([CH3:35])[C:29]([NH:31][CH2:32][CH2:33][OH:34])=[O:30])=[CH:22][CH:21]=1.COC(C1C(C)=C2C(NC3C=CC(OC4C=CC=CC=4OC(C(OC(C)(C)C)=O)(C)C)=CC=3)=C(C#N)C=NN2C=1)=O>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13]([NH:19][C:20]3[CH:42]=[CH:41][C:23]([O:24][C:25]4[CH:40]=[CH:39][CH:38]=[CH:37][C:26]=4[O:27][C:28]([C:29](=[O:30])[NH:31][CH2:32][CH2:33][OH:34])([CH3:35])[CH3:36])=[CH:22][CH:21]=3)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 21025099HCID 21025099, compoundHCID 22179696HCID 22179696, compoundHCID 221797422-[2-(4-amino-phenoxy)-phenoxy]-N-(2-hydroxy-ethyl)-2-methyl-propionamide

Product 1

HCID 21025115HCID 21025115, compoundYield 83%

Procedure

Compound 433E (146 mg, 83%) was prepared from 4-chloro-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester (Example 1D) (126 mg, 0.476 mmol) and 433D (165 mg, 0.500 mmol) by a route analogous to that used for the preparation of compound 388D. It is a cream-colored crystalline solid. LCMS Found: (M+H)+=558.1

Sources & evidence

ORD record
ord-f3d553aced7d4c5b9a929f70991adeef
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

Loading…