2-(Bromomethyl)benzonitrile → HCID 11524108, compound

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Reaction Steps

The title compound was prepared (100 mg, 75%) from 6-chloro-5-methyl-N-(piperidin -4-yl)thieno[2,3-d]pyrimidin-4-amine(95 mg, 0.336 m. mol) and 2-(bromomethyl) benzonitrile (73 mg, 0.37 m. mol) by following the general procedure described for Preparation 12. 1H NMR (400 MHz, CDCl3):δ 8.40 (s, 1H), 7.65 (d, 1H), 7.55 (m, 2H), 7. 35 (m, 1H), 5.30 (d, 1H), 4.25 (m, 1H), 3.7 (s, 2H), 2.85 (m, 2H), 2.50 (s, 3H), 2.40 (m, 2H), 2.10 (m, 2H), 1.40 (m, 2H). MS (ESI) m/z: Calculated: 397.92; Observed: 398.2 (M++1).

Provenance & Evidence