HCID 21026536, compound → HCID 21026546, compound

Participants

Reaction Steps

The title compound was prepared (97 mg, 81%) from (4-methyl-piperidin-4-yl)-(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-amine(150 mg, 0.28 mmol) and methanesulfonic acid 1-(3-fluoro-phenyl)-ethyl ester (61.1 mg, 0.28 mmol) by following the procedure described for preparation 12. 1H NMR (400 MHz, CDCl3): 6 (ppm) 8.38 (s, 1H), 7.20 (s, 1H), 6.89–6.79 (m, 3H), 3.91 (q, 1H), 2.80–2.74(m, 4H), 2.20–2.09(M, 2H), 1.90 (m, 2H), 1.89–1.85 (m, 4H), 1.55 (m, 4H), 1.31 (s, 3H); MS (SEI): m/z: Calculated: 424.2; Observed: 425.2 (M++1).

Provenance & Evidence